What can be done for a 17-year-old girl with localized juvenile periodontitis, a Class II malocclusion, and flared teeth? Is it possible to regain epithelial attachment and rebuild the bone architecture? Is it possible to achieve good esthetics and occlusion with conventional orthodontic treatment, or is an interdisciplinary approach needed? What sequence should be followed? What is the prognosis for the affected teeth in the long term? Our aim in this article was to review the literature and present a clinical case to shed more light on the subject. (Am J Orthod Dentofacial Orthop 2007;131: 268-76 )